Latest Advances in Lung Cancer Research

Researchers used multi-omics (genetic, protein-related) data to find new molecular weaknesses in non-small cell lung cancer and offering fresh avenues for therapies.

The FDA has approved a new drug called Datroway (datopotamab deruxtecan) for patients with EGFR-positive non-small cell lung cancer (NSCLC) who have already tried targeted therapy and chemotherapy. This approval marks an important step forward in lung cancer treatment.

A new study provides the first genetic evidence that air pollution causes DNA mutations leading to lung cancer in people who have never smoked, helping explain why lung cancer rates are rising among never-smokers worldwide, particularly women and those of Asian ancestry.

Clinical cancer informatics research applying computational methods or digital health technologies to improve cancer care and patient outcomes.

Researchers repurposed MDM2 inhibitor RG7388 as a potential targeted therapy for treating TP53-mutant non-small cell lung cancer patients.

Dr. Ramalingam emphasizes community oncologists must prioritize molecular testing and lung cancer screening to improve patient access to treatments.

Research develops hypoxic gene expression signatures to predict which muscle-invasive bladder cancer patients will respond to hypoxia-modifying therapies.

A major Australian-Canadian lung cancer screening study found that 73% of high-risk participants had incidental findings during baseline CT scans, with 10% requiring clinical follow-up, highlighting significant inconsistencies in how these findings are reported to doctors and raising important questions about standardization as Australia prepares to launch its national screening program in 2025.

Leading lung cancer specialists discuss revolutionary advances in treating EGFR-mutated non-small cell lung cancer, highlighting how new combination therapies like amivantamab plus chemotherapy are doubling progression-free survival and offering hope for patients with challenging complications like leptomeningeal metastases, while emphasizing practical strategies for managing treatment side effects in community practice.

Researchers developed RARE-seq, an ultrasensitive blood test detecting cell-free RNA that identifies early-stage lung cancer and monitors treatment resistance.

Oncologists have discovered that difficulties treating and managing the most common type of lung cancer, adenocarcinoma or non-small cell lung cancer, is related to a protein called agrin.

Researchers at Johns Hopkins Medicine have developed an innovative computer model that could significantly improve immunotherapy outcomes for lung cancer patients.