Latest Advances in Lung Cancer Research

Clinical cancer informatics research applying computational methods or digital health technologies to improve cancer care and patient outcomes.

Researchers repurposed MDM2 inhibitor RG7388 as a potential targeted therapy for treating TP53-mutant non-small cell lung cancer patients.

Research develops hypoxic gene expression signatures to predict which muscle-invasive bladder cancer patients will respond to hypoxia-modifying therapies.

A new JAMA review shows that small cell lung cancer, which affects 95% smokers and has only 12-30% five-year survival, is seeing breakthrough improvements with immunotherapy extending survival to 56 months for early-stage disease, though advanced cases remain challenging with most patients relapsing within three months.

Comprehensive review examining molecular mechanisms of cancer invasion and metastasis, identifying potential therapeutic targets for preventing cancer spread.

Final clinical trial results demonstrate selpercatinib’s safety and efficacy in treating RET fusion-positive non-small cell lung cancer patients.

Obesity paradox in lung cancer: Study finds obesity associated with improved survival in NSCLC patients, particularly those with preserved skeletal muscle quality and quantity.

Lung cancer mortality trends show significant disparities by sex, age, and ethnicity, with declining rates overall but persistent gaps in healthcare access and outcomes.

Neoadjuvant chemotherapy before surgery significantly improves survival in stage IIIA NSCLC, reducing death risk by 30% and increasing 5-year survival to 41% from 26%.

Tagrisso significantly improves survival in patients with unresectable stage III EGFR-mutated lung cancer, offering new hope for a longer life.

“Ground-glass opacity” on lung CT scans, a hazy sign of potential cancer, is linked to higher survival rates, emphasizing the importance of early detection.

Women’s lung cancer is often diagnosed late and treated less aggressively than men’s lung cancer, despite being the leading cause of cancer death among women.