Clinical Trials Research Targeted Therapy

New clinical trial shows improved survival rates and reduced risk of recurrence in patients taking a targeted therapy for NSCLC.

Trial Shows Significant Disease-free Survival for Patients Diagnosed With Non-small Cell Lung Cancer

New data from a Yale Cancer Center-led clinical trial shows improved rates of survival and reduced risk of recurrence in patients taking osimertinib, a targeted therapy for non-small cell lung cancer (NSCLC). NSCLC is the most common type of lung cancer, and for patients diagnosed with more advanced disease stages, cases tend to recur.

The phase III ADAURA clinical trial assessed the safety and efficacy of osimertinib in patients with surgically removed (completely resected) stage IB-IIA NSCLC, who were previously treated with or without adjuvant chemotherapy. The updated trial results were published in the Journal of Clinical Oncology on January 31.

The new data show there are ongoing benefits for patients with NSCLC taking osimertinib, including prolonged disease-free survival (DFS) over placebo, reduced risk of local and distant metastases (spread of tumor), and improved central nervous system DFS. These findings support the efficacy of adjuvant osimertinib in the patient population studied during the trial, researchers say.

“These data demonstrate a new paradigm demonstrating the importance of using targeted therapy against epidermal growth-factor-driven tumors as early as possible in the course of a patient’s disease,” said Roy S. Herbst, MD, PhD, lead author and principal investigator of the trial, Ensign Professor of Medicine (Medical Oncology), and professor of pharmacology and deputy director at Yale Cancer Center. “The results have led to a new standard of care in this disease setting.”

Herbst is also chief of medical oncology and director of the Center for Thoracic Cancers at Smilow Cancer Hospital and Yale Cancer Center, and assistant dean for translational research at Yale School of Medicine.

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