Dr. Vincent Lam, Assistant Professor of Oncology, Johns Hopkins University
Vincent K. Lam, M.D., an Assistant Professor of Oncology at Johns Hopkins, is a clinical/translational investigator with a special interest in lung cancer. Prior to joining the faculty at Johns Hopkins, Dr. Lam was on faculty at MD Anderson Cancer Center and previously completed his hematology/oncology fellowship at the University of Maryland. Dr. Lam’s research includes on-going efforts to develop the clinical utility of liquid biopsies in cancer. He has also led multiple early-phase immunotherapy clinical studies, including T-cell therapy trials in lung cancer. As an investigator with computational bioinformatics expertise, Dr. Lam is interested in applying genomic analytics to better understand why many lung cancers don’t respond to immunotherapy and to develop new immunotherapies for these patients.
Dr. Lam’s LCFA Funded research focuses on ALK+ lung cancer, which predominantly affects younger patients and those without significant smoking exposure. Similar to several other types of lung cancer (e.g. EGFR, ROS1), ALK+ lung cancer is generally not sensitive to current immunotherapies. Dr. Lam aims to comprehensively characterize the immune microenvironment in ALK+ lung cancer, including the use of novel T-cell studies to specifically guide the development of new therapies that can directly enhance the immune system’s anti-tumor response (e.g. vaccines).