A Blue Ribbon Panel of scientific experts was created to advise the National Cancer Advisory Board (NCAB). The Cancer Moonshot’s ambitious goal is to achieve a decade’s worth of progress in cancer prevention, diagnosis, and treatment in just 5 years. The Cancer Moonshot Task Force, headed by former Vice President Joe Biden, was directed to consult with external experts from relevant scientific sectors. This task force included the presidentially appointed NCAB. The Blue Ribbon Panel report describes 10 transformative research recommendations for achieving this goal.