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What Can We Help You Find?

  • How to detect lung cancer
    • How do you know if you are at risk for lung cancer?
    • Types of lung cancer
  • Understanding diagnosis
    • What Do I Need To Know About Genetic Mutation Testing?
    • I Am Going to Have My Tumor Tested for Mutations, What Should I Expect From the Procedure?
    • What If I’m Told I Can’t Get My Tumor Tested?
    • What is ALK-positive lung cancer?
    • What is EGFR-positive lung cancer and how is it treated?
    • What is ROS1-positive lung cancer and how is it treated?
    • Small Cell Lung Cancer Research: What You Need To Know
  • What are the latest treatments available besides chemotherapy and radiation?
    • Targeted Therapies
    • What Targeted Therapies Are Currently Available?
    • Immunotherapies
    • Should I be seeking a second opinion?
    • Is There a Type of Physician That Specializes in the Treatment of Lung Cancer?
    • I Have Found a Thoracic Oncologist That I Feel Comfortable With, What Is Next?
  • Lung Cancer Facts: 29 Statistics and Figures
  • Lung Cancer Resources

What Do I Need To Know About Genetic Mutation Testing?

It is very important to insist on having comprehensive molecular profiling of your lung cancer tissue.  
Some lung cancer patients report being told that there is no treatment option for them.  If no biomarker testing has previously been done for these patients, the next step is to make sure to get the molecular testing done, if at all possible.  For more information:

 

  • Don’t Guess Test – an initiative, supported by Lung Cancer Foundation of America, along with 15 other lung cancer advocacy organizations, aimed to expand awareness and educate patients about precision medicine and the importance of comprehensive biomarker testing in lung cancer.
  • NCI-Designated Cancer Centers – NCI-designated cancer centers deliver cutting-edge cancer treatments to patients in communities across the United States. Find a center near you and make an appointment for a second opinion.

What Size Tissue Sample Is Needed For Testing?

The more tissue, the better. In addition to core biopsy, tumor tissue can be obtained through bronchoscopy, lymph node biopsy, mediastinoscopy, CT-guided core needle biopsy, and via the VATS (Video-Assisted Thoracoscopic Surgery) procedure.

Where Do I Go To Have My Tissue Tested?

Many academic cancer centers currently offer comprehensive tumor testing. Outside of these facilities, testing can be done through various “CLIA-certified” companies and laboratories in the US. Your local oncologist should order these tests. Once ordered, the local hospital pathology department is responsible for sending your tumor tissue to the appropriate testing facility. Your local pathologist is an important member of your treatment team.

The Lung Cancer Mutation Consortium (LCMC) represents the largest national initiative to prospectively examine non-small cell lung cancer tumors, and match patients to the best possible therapies. Currently, the LCMC includes 16 leading cancer centers across the country.  The primary goal of the LCMC is to provide the most up-to-date care for lung cancer patients, while collecting valuable information about the frequency and characteristics of abnormalities found in lung tumors to further improve patient care for the entire lung cancer community.

How Long Does It Take To Get Results?

Once your tissue is sent for analysis, results will take approximately 1-4 weeks, depending on the amount and quality of the tumor tissue collected in the biopsy. The tests themselves are relatively straightforward. Processing time is determined by the time it takes your local hospital to locate, prepare, and send your tumor specimen to the testing facility. If your treatment is contingent on the test results, your doctor can request the test be expedited.

Are any blood tests available for testing my cancer?

VERISTRAT is a serum (blood) test that can be performed on all advanced non-small cell lung cancer patients. The test does not require tissue and can quickly predict whether a patient is likely to benefit from taking Tarceva® or standard chemotherapy regimens (lung cancer drugs) if the patient does not have the EGFR mutation. It is also useful in situations where it is not possible to obtain actual tumor tissue for analysis.

If There Is Little Sample Available, What Would Be Most Important To Test?

Currently, because of the direct therapeutic implications, EGFR and ALK would be the priority. Discuss this with your healthcare provider. Make sure to ask your doctor about next-generation sequencing.

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Our Mission

LCFA’s mission is the improvement in survivorship of lung cancer patients through the funding of transformative science.

While raising funds to support lung cancer research, LCFA will raise the public’s awareness and serve as a resource for patients or anyone seeking answers, hope, and access to updated treatment information, scientific investigation, and clinical trials.



Latest In Research

04/10
2021

Expand Targeted Therapy for Lung Cancer

From Fred Hutch News Service Seeking to expand targeted therapy for lung cancer, this NIH MERIT Award will support LCFA-Grant recipient, Dr. Alice Berger’s, efforts to target lung cancer-associated gene mutation. Targeted therapies…

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